.Rheumatoid arthritis is a chronic non suppurative inflammation of synovial joints.A genetic predisp

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.Rheumatoid arthritis is a chronic non suppurative inflammation of synovial joints.A genetic predisposition is strongly suspected (HLA DR1) .this leads to autoimmunity and formation of immune complexes with lgM antibodies in the serum , the immune complexes are deposited in the synovial membrane and intiate aself perpetuating chronic granulomatous inflammation of synovial membrane.

b.the arthritis is generally characterized by pain swelling and limitation of joint movement.pain and stiffness particularly in morning mark the begining of disease .it occurs due to cartilage worn off and fibrosis of capsule etc changes.

c.Rheumatoid factor- It is not specific for rheumatoid arthritis.It is present even in individuals who are not having rheumatoid arthritis.however it is one of the diagnostic criteria for rheumatoid arthritis.it is a protein by our immune system .it is an autoantibody. IgM is the most common rheumatoid factor .

D.As Rheumatoid arthritis is the autoimmune disorder, it release pro-inflammatory cytokines, such as TNF, that damage the joint tissue in people with RA can also lead to weight loss, muscle wasting and weakness.

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