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Which of the following correctly describes the pathophysiology of an acute haemolytic

transfusion reaction?

a.

Antibodies agglutinate with red cell antigens, embolise and occlude arterioles, causing a

febrile reaction and ischaemic damage

b.

IgG alloantibodies bind incompatible donor red cell antigens and trigger

complement-mediated destruction of red cell membranes

c. Phagocytic cells engulf and process foreign red cell antigens, present this to T (helper)

lymphocytes which triggers a cytokine storm

d.

In hypersensitive recipients, IgE binds donor red cell antigens resulting in an inflammatory

response that causes haemolysis

SCIENCE
HEALTH SCIENCE
NURSING
NURS 3102

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