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Damian has overdosed on paracetamol. 

The blood level of paracetamol, taken after 4 hours reveal that the level of paracetamol is at toxic levels. He has ordered the antidote N-acetylcysteine (NAC) to be administered as an intravenous infusion. 

 

With reference to pharmacokinetics, explain how the paracetamol would cause harm to Damian
Are the adverse effects of paracetamol seen immediately or would they been at a later stage in the patient’s care?
Discuss the pharmacodynamics of NAC and explain how it will help in Damian’s case

 

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