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In clinical treatment, randomized controlled trials (RCTs) are crucial for assessing the effectiveness of therapeutic interventions. For example, the study by the Diabetes Control and Complications Trial Research Group (Nathan et al., 1993) demonstrated that intensive treatment of diabetes significantly reduces the development and progression of long-term complications in insulin-dependent diabetes mellitus. This evidence has been added to clinical practice guidelines (Diabetes Control and Complications Trial Research Group, Nathan, D. M., Genuth, S., Lachin, J., Cleary, P., Crofford, O., Davis, M., Rand, L., & Siebert, C., 1993) to make sure that treatments are chosen after a careful review of their pros and cons. pharphrase
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