Question Answered Asked by maalzoubi – An investigator examined the

Question Answered Asked by maalzoubi – An investigator examined the association between the family history of Parkinson disease and the development of Parkinson disease using a prospective cohort study (see the Kaplan-Meier plot below). The bottom red line represents participants who have a family history of Parkinson disease, and the top blue line represents participants who do not have a family history of the disease. The following table presents hazard ratios for developing Parkinson disease during the study. Family history of Parkinson disease Hazard ratio (95% confidence interval) Unadjusted Adjusted* No Reference Reference Yes 2.0 (1.5, 2.5) 2.2 (1.6, 2.8) *Adjusted for race, sex, and smoking Question 3. Which of the following is true? A. Among people who have a family history of Parkinson disease, approximately 80% developed the disease after 4 years of follow-up. B. The survival curves account for potential differences in age between people with and without a family history of Parkinson disease. C. The median time to Parkinson disease was approximately 10 years greater among people with a family history compared to those without a family history. D. Participants were censored in this study when they either developed Parkinson disease, dropped out, died, or the study ended. E. After 8 years of follow-up, the difference in Parkinson disease-free survival was about 27%, comparing people with a family history to those without a family history. Question 4. Which of the following is true? A. The unadjusted relative risk of Parkinson disease is two times higher comparing people with a family history of the disease to those without a family history. B. Unadjusted survival with Parkinson disease is 2 years longer comparing people with a family history of the disease to those without a family history. C. Adjusted survival with Parkinson disease is 2.2 times higher comparing people with a family history of the disease to those without a family history holding race, sex, and smoking status constant. D. Death due to Parkinson disease is 2.2 times higher comparing people with a family history of the disease to those without a family history holding race, sex, and smoking status constant. E. The hazard ratios fail to account for potential differences in follow-up time between participants with and without a family history of Parkinson disease. SCIENCE HEALTH SCIENCE SOC 4083

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