Which of these is the best explanation of the portal theory with regard to how

Which of these is the best explanation of the portal theory with regard to how abdominal obesity may lead to metabolic problems? Group of answer choices Extended exposure of the hepatic portal vein to free fatty acids, glycerol, and hormones released by adipose tissue disturb the normal metabolism of glucose and lipids. Insulin increases in the blood make fat uptake more difficult in the adipose tissue. The difference between lipolysis of subcutaneous adipocytes in varying regions of the body cause disruption in the healthy metabolic responses. Insulin resistance in the liver leads to improved fat storage in the visceral area.

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