ASSIGNMENT: In this unit, you will complete the lab titled “Renal Physiology: Find the mode

ASSIGNMENT: In this unit, you will complete the lab titled “Renal Physiology: Find the mode of action of a diuretic drug”. You will develop a lab report describing the hypothesis, methods, and conclusions from this lab experience. By completing the lab report, you will demonstrate your ability to do the following: 1. Describe the overall objective and make a hypothesis. What is the overall purpose of the experiments or activities? Make a hypothesis. Recall that the hypothesis is a tentative and testable explanation of observations. For your entry make sure to include the following: (I) Include one statement that describes the overall objective in your own words. (II) Include brief statements for each of the three tested hypotheses for the mechanism of Drug X. Objective: Tested Hypotheses: Hypothesis (testable & tentative explanation) Mechanism 1: Mechanism 2: Mechanism 3: 2. Introduce relevant background knowledge on this topic. What have you learned in class or researched on your own that would help prepare for this simulation? Hint: You can review the “THEORY” section in the simulation, the lab activity page, and associated lecture course tutorials for relevant background information. For your entry make sure to include at least three important details from the lab simulation, “Theory” tab, Lab Manual, or other resources (such as the activity page background information and associated lecture tutorials) in your lab report that support the simulation activity. 3. Summarize the steps taken in the simulation. Explain all steps you completed, including the equipment and techniques you used. Hint: You can use the “MISSION” tab in the LabPad as inspiration Be sure to include the following: (I) Document each major step you completed, including the equipment and techniques you used. (II) Include enough detail for a classmate or lab instructor who is unfamiliar with the lab to be able to understand what you did. 4. Describe any obtained results. Explain all obtained results. Were these results expected or unexpected? Hint: You can use the “MEDIA” tab in the Lab Pad to revisit relevant images from the simulation Please be sure to include the following: (I) Document the results from the simulation. (II) Document whether the results rejected or did not reject your hypotheses, and briefly explain why. If differences were observed between the treatment and control groups, provide specific details regarding the observed differences (including numerical values when appropriate). Provide results as complete sentences. Results: Tested mechanism Reject Hypothesis? Why? Glomerular filtration rate Select Reject or Do Not Reject Antidiuretic hormones Select Reject or Do Not Reject Sodium reabsorption Select Reject or Do Not Reject Ion Absorption Experiment: Interpret the ion absorption experiment results presented below by explaining how measuring the rate of reabsorption when various ions were removed helped to determine the mechanism by which Drug X acts. Provide this information as complete sentences in the space below. Ion Absorption Interpretation: Image transcription text Reabsorbed Fluid Rates with Missing Ions Ions None None removed Na+ CI- Drug X? No Yes Yes Yes Yes Vin 2 2 2 2 2 Cin 1000 1000 1000 1000 1000 Vou… Show more 5. Discuss the conclusions and implications. How do your results relate to the original purpose and your hypothesis? Were there any systematic sources of error that could have affected the results? What did you learn? For your entry make sure to include the following: (I) Include a statement that briefly summarizes how the key results of the simulation relate to your original purpose and hypothesis. Be sure to include an explanation for how the data provide evidence that Drug X has a specific mode of action, and how you were able to rule out other mechanisms. (II) Include a statement that details any systematic sources of error you identified that could have affected the results. If the lab did not have any systematic sources of error, include a statement that acknowledges the lack of systematic error in the lab. (III) Include statements about 2-3 important ideas that you learned from the simulation.

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