Explain how the factor Age might influences

Explain how the factor Age might influences pharmacokinetic and pharmacodynamic processes in the following patient Case study assigned LM is an 89-year-old female resident of a long-term care facility who has been experiencing multiple falls, some resulting in injuries such as bruising and skin tears. Over the last 6 months, her ambulation status has declined from independent to wheelchair level. She complains of pain in her legs when walking more than short distances across the nursing unit. PMH: HTN Alzheimer’s disease Hypothyroidism Osteoarthritis Diabetes MEDICATIONS: Amlodipine 10 mg QD Donepezil 10 mg QHS Levothyroxine 88 mcg QAM Celecoxib 200 mg QD Furosemide 40 mg QAM Metformin 500mg, 1 BID Glyburide 5mg, 1 BID ALLERGIES: NKA SOCIAL HISTORY: Widowed with 2 adult children living in town, retired photographer and owner of an art supply store VITALS: LABS: Weight: 129 lbs TSH 2.45, Free T4 0.98 Height: 64 inches Na 135, K+ 3.4, Cl 99, CO2 25, BP: Supine = 177/82 Glucose 101 HR: 78 bpm WBC 7.0, RBC 4.5, Hgb 11.9, Hct 34.1, Plt 255 BUN 42, Cr 1.6, UA Clear eGFR: 45 ml/min PE: HEENT: Normocephalic, no evidence of trauma, PERRLA, EOMI CV: RRR Respiratory: Clear to auscultation bilaterally Abdomen: Soft, non-tender, no masses or guarding G/U: Skin intact, assisted with toileting and personal hygiene by staff Extremities: Bilateral 2+ edema to lower extremities; skin dry, dark bruising and skin tear to right elbow and forearm Neuro: Alert and oriented to person only. MMSE 18/30, stable over last 12 months PAIN ASSESSMENT: Faces pain scale: No pain occurs at rest, upon walking, pain is moderate to severe SCIENCE HEALTH SCIENCE NURSING NURS 6521

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