Extinction learning was achieved by exposing animals

Extinction learning was achieved by exposing animals to ____________________________. a. repeated presentations of the tone alone b. repeated tone-shock pairings c. lower shock intensities d. nothing at all The main effects in the CB1-/- mice were attributed to alterations in pain perception to the electric shocks. a. True b. False The main effects in the CB1-/- mice were attributed to non-specific alterations in general locomotion. a. True b. False What pharmacological agent (i.e., drug) did the authors used to replicate the main effects on fear extinction in wild-type mice? Wild-type mice are controls with normal genetic profiles. a. CB1 agonist Nabiximol b. CB1 agonist AM-2201 c. CB1 antagonist Rimonabant d. CB1 antagonist SR141716A Image transcription text The endogenous cannabinoid system controls extinction of aversive memories Giovanni Marsicano* #, Carsten … Show more Image transcription text Treatment of wild-type mice with the CBI antagonist SR141716A mimicked the phenotype of CBI-deficient mice… Show more Image transcription text shock ( conditioning). After conditioning animals froze when Competing Interests statement Unconcrooned to-mil:… Show more Image transcription text re-exposed to the tone. This response served as an indicator of aversive memory, and is gradually extinguished on repeat… Show more Image transcription text F1,14 = 0.18, P = 0.675; genotype X day interaction: F2,28 = 1.61, P = 0.217; Supplementary Information). We… Show more Image transcription text b MPFC 75 LICH AFA 250 2-AG 50 Per cent frocking por 60 s tondo pmol pering of loc extract Per cent fromking par 6… Show more Image transcription text and CBI mice were observed during acute tone presentation long-term extinction of the freezing response as compared … Show more Image transcription text mental adaptations to life-long absence of CBI, and cannot be easily attributed to the lack of CBI during LTP induction…. Show more Image transcription text As several recent studies indicate an involvement of CBI in GABA-mediated synaptic transmission in hippoca… Show more Image transcription text Extinction of aversive memories is thought to be an active mnemonic process . As a new memory, it shares several attribu… Show more Image transcription text The role of GABA-mediated transmission for extinction is, however, controversial?”. Within the amygdala, CBI immun… Show more Image transcription text aversive memories mediated by CBI. It remains to be shown whether CBI is not only involved in extinction of aversive… Show more Image transcription text Overall, our findings suggest that the endogenous cannabinoid system could represent a therapeutic target f… Show more Image transcription text Measurement of endocannabinoids C57BL/6JOlaHed mice were randomly assigned to three groups (R = 2… Show more SCIENCE HEALTH SCIENCE NURSING RIZAL 9181

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