ihuman Ben Buddy 75-year-old with COPD 1. Situation, Background, Assessment,

Researchers are evaluating dosing of carbamazepine for acute mania. Since carbamazepine is both a substrate of cytochrome P450 3A4 and an inducer of this same enzyme, an upward dosage adjustment is often required during treatment. All patients with a diagnosis of bipolar I disorder at a state psychiatric facility who have been resistant to trials of standard medications are eligible for the study and are started on carbamazepine after informed consent and assessment of baseline manic symptoms. The reported results of the study include the initial dosage of carbamazepine required for resolution of acute mania, the carbamazepine level at the time of resolution, the duration of initial effectiveness, the dosage increase required to regain control of the manic symptomatology, and the carbamazepine level at the point of regaining symptom control. They enrolled 200 patients in the study. The results would have been normally distributed, however, there were six patients who required significantly higher dosage increases to regain control of their manic symptoms. Which of the following is most consistent with the findings or design of this study? It has a noninferior research design due to the requirement for resistance to standard medications It has a quasiexperimental rather than experimental design It is controlled for metabolizer status of cytochrome P450 3A4 The median is better than the mean or mode for the measure of central tendency

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