Paraphrase: In addition to these factors, the individual’s underlying physiology

Anyone who has suffered with an acute or chronic illness is probably very appreciative for whatever drugs are available to cure or manage the disease. In the United States, the Food and Drug Administration (FDA) is the governmental agency that oversees the drug development, testing, and monitoring process. (See http://www.fda.gov/Drugs/.) Developing new drugs that safely address particular medical issues without producing unpleasant or dangerous side-effects is a very long and expensive process, often taking 10 to 15 years of work and costing an average of $4 billion. The long lead-time for bringing drugs to markets is mostly due to required clinical trials. Thus, drug manufacturers have to make very important, high-stakes decisions when they consider whether or not to place a new drug into the clinical trials process.

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