Question 1: go to the website https://www.bweber.net/pmx-apps/Links to an external

Question 1: go to the website https://www.bweber.net/pmx-apps/Links to an external site.. You will see a number of different pharmacokinetic, pharmacodynamic, and PKPD simulations that can be run on this site. You are now tasked to model 2 drugs in development in 3 different ways: Multiple injection into a one-compartment model, Multiple oral administration into a one-compartment model, Multiple oral administration into a one-compartment model with a direct effect model. The 2 drugs you are tasked to model are quite similar but have some pharmacokinetic and pharmacodynamic differences. Here are the respective pharmacokinetic and pharmacodynamic parameters: 1-Multiple injection (i.v.) into a one-compartment model: for each of the two drugs, try increments of 10, 50, or 100 mg dosing and intervals of 6, 12, or 24h dosing and compare when each of them reaches steady-state concentrations. Write in detail how the two drugs differ and present in your answer screenshots for each of the doses and dosing intervals. Multiple oral administration into a one-compartment model: for both drugs, again try increments of 10, 50, or 100 mg dosing and 6, 12, and 24h dosing intervals. How do the oral doses compare to the i.v. (injection) doses? Which oral dose and interval does best compare to the respective i.v. dose? Provide screenshots with your response. Image transcription text Drug 1 (blue drug): Oral bioavailability (F) 0.89 Module 4 Assignment At 40 Points Possible Due: Mon Sep 30, 2024 11:59pm In Progress Attempt 1 NEXT … Show more Multiple oral administration into a one-compartment model with a direct effect model: when choosing the better drug for clinical trials, we need to concern ourselves with both effectiveness and safety. For drug 1 to be effective and safe, at steady state concentrations at least 70% of receptors need to be occupied. At the same time, the peak blood concentration cannot exceed 2.5 mg/L due to adverse effects. For drug 2 to be effective and safe, a minimum of 50% of receptors need to be occupied at steady state concentrations. This drug is more toxic so the peak concentrations cannot exceed 2.0 mg/L. Evaluate both drugs and determine which can actually be used for clinical trials. You need to provide a dose and dosing interval for the respective drug you think can be used successfully and safely in clinical trials. Justify your answer in detail providing screenshots of simulated models.

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