Abstral® sublingual tablet (containing contains 100, 200,

Abstral® sublingual tablet (containing contains 100, 200, 300, 400, 600, or 800 micrograms of fentanyl as citrate) is indicated for the management of breakthrough pain in adults with cancer who are already receiving maintenance opioid therapy for chronic pain. Pharmacokinetic studies for the medicine revealed that the mean maximal plasma concentrations of fentanyl range from 0.2 to 1.5 nanogram/mL (after administration of 100 to 800 microgram tablet) and are reached within 22.5 to 240 minutes. – Considering the physicochemical properties of the drug and physiological factors in the oral cavity, discuss the rational for formulating the drug fentanyl as a sublingual tablet formulation – Compared with Abstral® tablets, “Zofran Zydis wafer” is administered by placing each dosage on top of the tongue. Identify whether this wafer is designed for local or systematic drug delivery. Outline the differences in both absorption pathways and the formulation of the two dosage forms

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