Case Study: A school physical examination of
Case Study: A school physical examination of a 17-year -old boy showed less pubic and axillary hair than those of peers, penis and scrotum that were smaller, breast tissue since age 13, no erections or nocturnal emissions, and no adolescent growth spurt. Sleeve and pant lenghths increased every 4 to 6 months. Questions: 1) At what level is the defect in this case? 2) What diagnostic possibilities would explain the endocrine data? 3) What treatment (s) would be available to a. Treat his androgen deficiency? b. Allow him to father children if he wanted fertility? 4) His appearance shows the defect occurred: a. Prior to birth ( during fetal life) b. After birth (postnatal) PE Height 73 inches Arm span 74 inches Weight 148 lb. BP 110/70 mm Hg Pulse 69 bpm Hair Scant axillary and pubic Breasts Moderate gynecomastia, 3cm Genitalia Penis, 4.5cm Testes 1.5 x 1x 1cm, bilaterally (normal, > 4.5 x 3 x 3 cm Laboratory, total 115ng/dL (normal, 300-1,000) LH 42 mU/mL (normal, adult, 3-18) Karyotype 47, XXY
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