David is a 41-year-old male, who has

David is a 41-year-old male, who has made an appointment to see his GP for his biannual health check. He tells the doctor that he has been feeling “a bit puffed” walking around the course during his weekly game of golf and that he seems to be urinating more frequently of late. David reports he has gained nine kilos since his 30th birthday, and his waist measurement has expanded. He laughs this off as “middle-aged spread” and says his wife tells him he needs to watch what he eats and drink less alcohol. David works as a software engineer, which he has been finding very stressful of late, and spends a lot of his time in the office sitting in front of a computer, snacking on his favourite salt and vinegar chips. David and his wife are keen to start a family but have not yet been successful in conceiving. On the advice of his doctor, David has been taking aspirin in the evenings for the past 18 months to lower his risk of heart attack and Zocor® to address cholesterol. Topic: Pharmacology (PLEASE PROVIDE 3 REFERENCES) Under the advice of his doctor, David has taken Zocor® tablets each evening for the past 18 months. Q3. Discuss the route of administration, which route the drug is likely to be excreted after administration, and its likely bioavailability. Justify your response by discussing whether the drug would be subjected to hepatic first pass. Q4. To help with weight loss, a friend has advised David to drink grapefruit juice with his meals. As a health care professional, would you consider this to be a good idea for David? In your answer, discuss the role of the liver in the administration of Zocor and grapefruit juice?

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