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Generalized anxiety disorder (GAD) is the most common anxiety disorder experienced among patients with anxiety. The disorder is characterized by various symptoms such as excessive fear and worries about different issues, events, and activities (Slee et al., 2019). An individual with this disorder is usually terrified by a range of things rather than specific ones, which is why the condition is considered a ‘generalized’ disorder. The person also tends to experience emotions and bodily effects such as racing heartbeat, muscle tightness, and sleepiness. However, there are several options that can be used for the treatment of the disorder. Therefore, various treatment options for GAD have been discussed with regard to the pharmacodynamics and pharmacokinetics associated with anxiolytic medications.
SSRIs and SNRIs
SSRIs stand for selective serotonin reuptake inhibitors, while SNRIs refer to selective serotonin-norepinephrine reuptake inhibitors (Yu et al., 2018). They are the first-line treatment options for GAD due to their favorable benefit-to-risk ratio. After a patient has used these medications, he or she might experience anxiolytic effects within 2-4 weeks. The patient is also likely to experience adverse effects within the first two weeks. Patients may experience withdrawal symptoms varying in severity when switching to SNRIs from SSRIs (Slee et al., 2019). However, the severity of the effects varies among patients based on age since this aspect tends to affect pharmacodynamics and pharmacokinetics. However, the withdrawal symptoms experienced in this case are minimal compared to those experienced when a patient stops using benzodiazepine. This implies that paroxetine side effects are more common compared to fluoxetine or sertraline.
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